

LSD and psilocybin are non-lethal and do not develop physical dependencies. Youd have to take and insane amount to die. You are advised to be watched if you are new to the drugs as they are HIGHLY mind altering. It’s not like alcohol or weed, your perception of things completely change. An experienced user is fine on a standard dose alone. But that’s not what LD-50 measures anyway, it deals with direct toxicity. Its not someone jumping through a window because they are tripping and now think they can fly.
LSD is non-habit forming for three reasons. 1) you pretty much gain an immediate and temporary tolerance. 2) the trips are so intense, abusing it everyday probably hints to you having some mental disorder instead of some dependency. They can be exhausting. 3) it’s not physically addictive, your body will not form a dependency on it, in fact it’s processed out of the brain with minutes to hours of consumption even if its effects last for much longer.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4910402/